Dr. Soulafa Mamlouk

Expertise

Soulafa Mamlouk received her PhD in cancer immunology at the Technical University of Dresden in 2012. She then moved to Berlin and joined the group of Prof. Sers for her Post-Doctoral research as part of the DKTK (German Cancer Consortium). Her work has focused on the genetic heterogeneity of colorectal cancer (CRC), where she investigated several levels of heterogeneity with regards to DNA alterations, both SNVs (single nucleotide variant) and CNVs (copy number variant). Recently, she worked on  the evolution of CRC from an adenomatous growth to a carcinoma using matched patient samples. In 2020 Soulafa received independent funding from the German Research foundation (DFG) to investigate the evolution of resistance to cancer therapy in CRC. In this project, she and her team will follow single cells and patient derived organoids as they struggle to adapt and alter their fitness landscape while under harsh cancer treatments.

Selected Publications:

1. Mamlouk S, Simon T, Tomás L, Wedge DC, Arnold A, Menne A, et al. Malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression. BMCBiology. 2020;18:116.

2. Gastl B, Klotz-Noack K, Klinger B, Ispasanie S, Salib KHF, Zuber J, et al. Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe. Cell Death Dis. 2020;11(7).

3. Simon T, Mamlouk S, Riemer P, Bormann F, Klinger B, Menne A, et al. An Integrative Genetic, Epigenetic and Proteomic Characterization of Pancreatic Neuroendocrine Neoplasms (PanNENs) defines Distinct Molecular Features of α- and β-cell like Subgroups. bioRxiv. 2020;

4. Jurmeister P, Schöler A, Arnold A, Klauschen F, Lenze D, Hummel M, et al. DNA methylation profiling reliably distinguishes pulmonary enteric adenocarcinoma from metastatic colorectal cancer. Mod Pathol. 2019;

5. Otto R, Rössler JN, Sers C, Mamlouk S, Leser U. Robust in-silico identification of Cancer Cell Lines based on RNA and targeted DNA sequencing data. Sci Rep. 2019;

6. Mamlouk S, Childs LH, Aust D, Heim D, Melching F, Oliveira C, et al. DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer. Nat Commun. 2017;8:14093.

7. Mamlouk S, Kalucka J, Singh RP, Franke K, Muschter A, Langer A, et al. Loss of prolyl hydroxylase-2 in myeloid cells and T-lymphocytes impairs tumor development. Int J Cancer. 2014;

8. Kalucka J, Ettinger A, Franke K, Mamlouk S, Singh RP, Farhat K, et al. Loss of Epithelial {HIF} Prolyl Hydroxylase-2 ({PHD2)} Accelerates Skin Wound Healing in Mice. Mol Cell Biol. 2013;

9. Singh RP*, Franke K*, Kalucka J*, Mamlouk S*, Muschter A, Gembarska A, et al. HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress. Blood. 2013. *equal contribution

10. Mamlouk S, Wielockx B. Hypoxia-inducible factors as key regulators of tumor inflammation. International Journal of Cancer. 2013.

11. Franke K*, Kalucka J*, Mamlouk S*, Singh RP*, Muschter A, Weidemann A, et al. HIF-1α is a protective factor in conditional PHD2-βdeficient mice suffering from severe HIF-2-induced excessive erythropoiesis. Blood. 2013; *equal contribution

12. Kalucka J, Ettinger A, Franke K, Mamlouk S, Singh RP, Farhat K, et al. Loss of Epithelial Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Accelerates Skin Wound Healing in Mice. Mol Cell Biol. 2013;

13. Klotzsche-Von Ameln A, Muschter A, Mamlouk S, Kalucka J, Prade I, Franke K, et al. Inhibition of HIF prolyl hydroxylase-2 blocks tumor growth in mice through the antiproliferative activity of TGFβ. Cancer Res. 2011;

14. Yeghiazaryan K, Mamlouk S, Trog D, Moenkemann H, Braun M, Kuhn W, et al. Irradiated breast cancer patients demonstrate subgroup-specific regularities in protein expression patterns of circulating leukocytes. Cancer Genomics and Proteomics. 2007;

Links

• June 2021: Awarded the Female Independence Award 2021 by the Berlin School of Oncology (BSIO), see link
• September 2020: Publikation des Papers "Malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression" in der Zeitschrift BMC Biology
• August 2020: Deutsche Forschungsgemeinschaft (DFG) Funding for independent research in CRC cancer evolution, see project details
• June 2019: EMBO short term fellowship to work in the lab of Prof. Posada
• November 2017: Awarded the Curt Meyer Gedächtnispreis by the Berliner Krebsgesellschaft, see press release
• January 2017: Publication of the paper "DNA Copy Number Changes Define Spatial Patterns of Heterogeneity in Colorectal Cancer" in Nature Communication
• September 2016: Publication of the paper "SoFIA: A Data Integration Framework for Annotating High-Throughput Datasets" together with Liam Childs in Bioinformatics

Networking

Institute of Pathology
Campus Charité Mitte (CCM)

Diagnostic Laboratory and Preventive Medicine (CC 5)

Campus Charité Mitte
(CCM)