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Markus Morkel studied Biology at the University Würzburg and received his Dr. rer. nat. in Molecular Biology from the Humboldt University, Berlin. He continued his research as a postdoc in Professor Walter Birchmeier's lab at the Max-Delbrück-Centrum (MDC) and as a research group leader in the Department of Developmental Biology at the Max-Planck-Institute for Molecular Genetics. His scientific background is in developmental biology and in cancer research, two fields sharing a common interest in signals controlling cell phenotypes and cell developmental trajectories.
Projects employ patient-derived tissues and organoids to decipher contributions of individual oncogenes to cancer cell signaling networks, with a focus on Wnt/β-catenin, PI3K-AKT, and MAPK. Fluorescent reporters and single cell methods such as CyTOF and single cell RNA sequencing are used to assess cell heterogeneity on the levels of the signaling network and the transcriptome, respectively. Generally, the studies are designed to understand how oncogenic signals shape cancer cell phenotypes with the translational aim to identify novel vulnerabilities of cancer signal transduction networks.
Markus Morkel is head of BIH core facility Bioportal Single Cells
Teaching and trainee development:
Program Director of the Master's Program in Molecular Medicine
Faculty member of graduate school BSIO
Elective Module M24 Personalisierte Krebsmedizin (Modelstudiengang Medizin)
Lectures on Oncogenes, Tumor Suppressors and Signaling Networks (Master's Program Molecular Medicine)
M19 Molecular Charakteristics (Modelstudiengang Medizin)
M23 Good Scientific Practice (Modulstudiengang Medizin)