Meta menu:

From here, you can access the Emergencies page, Contact Us page, Accessibility Settings, Language Selection, and Search page.

Open Menu

AG 3D Cancer Genomics

Welcome to the website of the 3D Cancer Genomics working group.

You are here:

Focus of the 3D Cancer Genomics Working Group

Our focus is to understand how recurrent changes to the structure of cancer genomes impact the activation of oncogenes and resulting cancer growth. We can identify such significantly recurrent structural variants (SVs) by analyzing human cancer genomes from hundreds of patients and their tumors. To interpret how, with these recurrent SVs, cancers hijack gene regulation through novel 3D genome interactions we integrate epigenetic data from tumor samples and cell lines and validate our findings experimentally using CRISPR-based genome engineering approaches. With this approach, we aim to find biomarkers and therapies that target the aberrant gene regulation in cancer.

For more info please visit: