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International Cancer Genome Consortium: Molecular Mechanisms in Malignant Lymphoma by Sequencing (ICGC MMML-Seq)
The International Cancer Genome Consortium (ICGC) aims to obtain a comprehensive description of genomic, transcriptomic and epigenomic changes in 50 different tumor types and/or subtypes which are of clinical and societal importance across the global. This data will be shared with the scientific community in order to accelerate the fundamental research of the mechanisms of tumor formation and the development of effective treatment strategies.
Our group participates in one of the German projects (ICGC MMML-Seq) of the consortium, which studies lymphoma. In total 250 germinal-center-derived lymphoma (Burkitt lymphoma, Diffuse large B-cell lymphoma, Follicular lymphoma) will be analyzed by high-throughput sequencing. Within this project our group is actively involved in the selection of the tumor tissue and responsible for analyte extraction (DNA, RNA) from tumor and germline samples, as well as the quality control of the analytes. Furthermore we take part in the work package dealing with the sequencing of small non-coding RNA, including micro RNAs.