Das Bild zeigt rechts ein Trichterglas mit blauer Flüssigkeit und Glasstab zum Umrühren. Daneben steht ein Reagenzglasständer mit Reagenzgläsern, die ebenfalls blaue Flüssigkeit enthalten. Im Hintergrund ist ein Forscher zu sehen, der in der rechten Hand eine Pipette hält.

Representative microscopic images of each case (TBC Gallery)

Please klick on the thumbnails to enlarger the images.

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Case 1

Image 1a: lung with confluent caseous necrosis (HE 25x)
Image 1a
Image 1b: necrosis with little perinecrotic inflammation (HE 50x)
Image 1b
Image 1c: necrosis and perinecrotic inflammatory infiltrate (HE 100x)
Image 1c
Image 1d: necrosis and perinecrotic inflammatory infiltrate (HE 200x)
Image 1d

PCR status = positive

Image 1a: lung with confluent caseous necrosis (HE 25x)
Image 1b: necrosis with little perinecrotic inflammation (HE 50x)
Image 1c: necrosis and perinecrotic inflammatory infiltrate (HE 100x)
Image 1d: necrosis and perinecrotic inflammatory infiltrate (HE 200x)

Case 2

Image 2a: artery (HE 25x), same case/patient as case 3
Image 2a
Image 2b: arteriosclerosis with calcifications (HE 25x)
Image 2b
Image 2c: inflammatory infiltrate within hemorrhage/necrosis (HE 200x)
Image 2c
Image 2d: intima with hemorrhage (HE 100x)
Image 2d
Image 2e: arteriosclerosis with calcification and inflammation (HE 50x)
Image 2e
Image 2f: hemorrhage, necrosis (HE 100x)
Image 2f

PCR status = positive

Image 2a: artery (HE 25x), same case/patient as case 3
Image 2b: arteriosclerosis with calcifications (HE 25x)
Image 2c: inflammatory infiltrate within hemorrhage/necrosis (HE 200x)
Image 2d: intima with hemorrhage (HE 100x)
Image 2e: arteriosclerosis with calcification and inflammation (HE 50x)
Image 2f: hemorrhage, necrosis (HE 100x)

Case 3

Image 3a: lung / aorta (HE 25x), same patient/case as case 2
Image 3a
Image 3b: confluent necrosis and hemorrhage (HE 25x)
Image 3b
Image 3c: caseous necrosis/granuloma with giant cells (HE 50x)
Image 3c
Image 3d: necrosis / perinecrotic tissue (HE 50x)
Image 3d
Image 3e: non-caseous ("sarcoid-like") granuloma (HE 100x)
Image 3e

PCR status = positive

Image 3a: lung / aorta (HE 25x), same patient/case as case 2
Image 3b: confluent necrosis and hemorrhage (HE 25x)
Image 3c: caseous necrosis/granuloma with giant cells (HE 50x)
Image 3d: necrosis / perinecrotic tissue (HE 50x)
Image 3e: non-caseous ("sarcoid-like") granuloma (HE 100x)

Case 4

Image 4a: liver with granulomas (HE 25x)
Image 4a
Image 4b: non-caseous granuloma with Langhans-type giant cells (HE 100x)
Image 4b
Image 4c: granuloma with Langhans-type and non-Langhans giant cells (HE 100x)
Image 4c
Image 4d: non-caseous granuloma (HE 200x)
Image 4d
Image 4e: caseous granuloma with minute (Score 1) necrosis (HE 200x)
Image 4e

PCR status = negative

Image 4a: liver with granulomas (HE 25x)
Image 4b: non-caseous granuloma with Langhans-type giant cells (HE 100x)
Image 4c: granuloma with Langhans-type and non-Langhans giant cells (HE 100x)
Image 4d: non-caseous granuloma (HE 200x)
Image 4e: caseous granuloma with minute (Score 1) necrosis (HE 200x)

Case 5

Image 5a: lymph node and paranodal soft tissue necrosis (HE 25x)
Image 5a
Image 5b: extensive necrosis and skeletal muscle (HE 25x)
Image 5b
Image 5c: necrosis and perinecrotic inflammation (HE 100x)
Image 5c
Image 5d: necrosis and perinecrotic inflammation (HE 50x)
Image 5d
Image 5e: necrosis/inflammatory infiltrate (HE 100x)
Image 5e

PCR status = positive

Image 5a: lymph node and paranodal soft tissue necrosis (HE 25x)
Image 5b: extensive necrosis and skeletal muscle (HE 25x)
Image 5c: necrosis and perinecrotic inflammation (HE 100x)
Image 5d: necrosis and perinecrotic inflammation (HE 50x)
Image 5e: necrosis/inflammatory infiltrate (HE 100x)

Case 6

Image 6a: lymph node with confluent necrosis-HE25x
Image 6a
Image 6b: granuloma with pseudotuberculoid (cellular) necrosis (HE 100x)
Image 6b
Image 6c: caseous and cellular necrosis (HE 100x)
Image 6c
Image 6d: non-caseous granuloma with Langhans-type giant cell (HE 100x)
Image 6d
Image 6e: non-Langhans giant cell (HE 200x)
Image 6e
Image 6f: non-caseous granuloma with microabscess/cellular necrosis (HE 200x)
Image 6f
Image 6g: non-caseous granuloma with giant cells (HE 100x)
Image 6g

PCR status = negative

Image 6a: lymph node with confluent necrosis (HE25x)
Image 6b: granuloma with pseudotuberculoid (cellular) necrosis (HE 100x)
Image 6c: caseous and cellular necrosis (HE 100x)
Image 6d: non-caseous granuloma with Langhans-type giant cell (HE 100x)Image 6e: non-Langhans giant cell (HE 200x)
Image 6f: non-caseous granuloma with microabscess/cellular necrosis (HE 200x)Image 6g: non-caseous granuloma with giant cells (HE 100x)

Case 7

Image 7a: lymph node with subtotal (Score 4) necrosis (HE 50x)
Image 7a
Image 7b: caseous necrosis and giant cells (HE 100x)
Image 7b
Image 7c: necrosis and perinecrotic inflammation with Langhans-type giant cells (HE 100x)
Image 7c
Image 7d: caseous necrosis with giant cells (HE 200x)
Image 7d
Image 7e: Non-Langhans-type giant cell (HE 200x)
Image 7e

PCR status = negative

Image 7a: lymph node with subtotal (Score 4) necrosis (HE 50x)
Image 7b: caseous necrosis and giant cells (HE 100x)
Image 7c: necrosis and perinecrotic inflammation with Langhans-type giant cells (HE 100x)
Image 7d: caseous necrosis with giant cells (HE 200x)
Image 7e: Non-Langhans-type giant cell (HE 200x)

Case 8

Image 8a: fetal lung, negative control (HE 100x)
Image 8a

PCR status = negative

Image 8a: fetal lung, negative control (HE 100x)

Case 9

Image 9a: lung with confluent caseous necrosis (HE 25x)
Image 9a
Image 9b: necrosis and giant cells (HE 100x)
Image 9b
Image 9c: necrosis, perinecrotic inflammation with giant cells, strong perinecrotic fibrosis/sclerosis, focal calcification (HE 100x)
Image 9c
Image 9d: granuloma with caseous and cellular necrosis (HE 100x)
Image 9d
Image 9e: perinecrotic infiltrate (HE 200x)
Image 9e

PCR status = positive

Image 9a: lung with confluent caseous necrosis (HE 25x)
Image 9b: necrosis and giant cells (HE 100x)
Image 9c: necrosis, perinecrotic inflammation with giant cells, strong perinecrotic fibrosis/sclerosis, focal calcification (HE 100x)
Image 9d: granuloma with caseous and cellular necrosis (HE 100x)
Image 9e: perinecrotic infiltrate (HE 200x)

Case 10

Image 10a: lung with necrosis (HE 50x)
Image 10a
Image 10b: lymph node with confluent caseous necrosis (HE 50x)
Image 10b
Image 10c: necrosis within lymph node (HE 100x)
Image 10c
Image 10d: caseous lymph node necrosis (HE 200x)
Image 10d

PCR status = positive

Image 10a: lung with necrosis (HE 50x)
Image 10b: lymph node with confluent caseous necrosis (HE 50x)
Image 10c: necrosis within lymph node (HE 100x)
Image 10d: caseous lymph node necrosis (HE 200x)

Case 11

Image 11a:  fetal lung, negative control (HE 50x)
Image 11a

PCR status = negative

Image 11a: fetal lung, negative control (HE 50x)

Case 12

Image 12a:  lymph node with confluent caseous necrosis (HE 50x)
Image 12a
Image 12b: granuloma with caseous necrosis (HE 100x)
Image 12b
Image 12c:  necrosis and perinecrotic inflammation (HE 200x)
Image 12c
Image 12d:  necrosis and perinecrotic inflammation (HE 200x)
Image 12d

PCR status = positive

Image 12a: lymph node with confluent caseous necrosis (HE 50x)
Image 12b: granuloma with caseous necrosis (HE 100x)
Image 12c: necrosis and perinecrotic inflammation (HE 200x)
Image 12d: necrosis and perinecrotic inflammation (HE 200x)

Case 13

Image 13a:  lung with pleuritis (HE 25x)
Image 13a
Image 13b:  lung with caseous necrosis (HE 50x)
Image 13b
Image 13c:  necrosis with strong perinecrotic circular sclerosis (HE 100x)
Image 13c
Image 13d:  non-caseous sarcoid-like granuloma (HE 200x)
Image 13d

PCR status = positive

Image 13a: lung with pleuritis (HE 25x)
Image 13b: lung with caseous necrosis (HE 50x)
Image 13c: necrosis with strong perinecrotic circular sclerosis (HE 100x)
Image 13d: non-caseous sarcoid-like granuloma (HE 200x)

Case 14

Image 14a:  lung with caseous necrosis (HE 50x)
Image 14a
Image 14b: lung with caseous necrosis (HE 200x)
Image 14b
Image 14c:  inflammatory infiltrate (HE 100x)
Image 14c
Image 14d:  caseous necrosis with little (score 1) perinecrotic inflammation (HE 100x)
Image 14d
Image 14e:  necrosis of low to medium (score 3) extent (HE 50x)
Image 14e

PCR status = positive

Image 14a: lung with caseous necrosis (HE 50x)
Image 14b: lung with caseous necrosis (HE 200x)
Image 14c: inflammatory infiltrate (HE 100x)
Image 14d: caseous necrosis with little (score 1) perinecrotic inflammation (HE 100x)
Image 14e: necrosis of low to medium (score 3) extent (HE 50x)

Case 15

Image 15a:.  fetal lung, negative control (HE 50x)
Image 15a

PCR status = negative

Image 15a: fetal lung, negative control (HE 50x)

Case 16

Image 16a:  lung with non-caseous (sarcoid-like) granulomatous inflammation (HE -50x)
Image 16a
Image 16b: cellular (pseudotuberculoid) necrosis (HE 50x)
Image 16b
Image 16c:  cellular (pseudotuberculoid) necrosis (HE 100x)
Image 16c
Image 16d:  caseous granuloma (HE 200x)
Image 16d
Image 16e:  non-caseous (sarcoid-like) granuloma with Langhans and non-Langhans giant cells (HE 200x)
Image 16e
Image 16f:  giant cell (HE 400x)
Image 16f

PCR status = negative

Image 16a: lung with non-caseous (sarcoid-like) granulomatous inflammation (HE -50x)
Image 16b: cellular (pseudotuberculoid) necrosis (HE 50x)
Image 16c: cellular (pseudotuberculoid) necrosis (HE 100x)
Image 16d: caseous granuloma (HE 200x)
Image 16e: non-caseous (sarcoid-like) granuloma with Langhans and non-Langhans giant cells (HE 200x)
Image 16f: giant cell (HE 400x)

Case 17

Image 17a: ex vivo BCG-infected lung tissue, HOPE fixation, positive control (HE 50x)
Image 17a
Image 17b:  ex vivo BCG-infected lung tissue, HOPE fixation, positive control (HE 50x), same case/patient as case 18
Image 17b

PCR status = positive

Image 17a: ex vivo BCG-infected lung tissue, HOPE fixation, positive control (HE 50x)
Image 17b: ex vivo BCG-infected lung tissue, HOPE fixation, positive control (HE 50x), same case/patient as case 18

Case 18

Image 18a:  ex vivo BCG-infected lung tissue, HOPE fixation, positive control (HE 50x), same case/patient as case 17
Image 18a

PCR status = positive

Image 18a: ex vivo BCG-infected lung tissue, HOPE fixation, positive control (HE 50x), same case/patient as case 17

Case 19

Image 19a:  prostate with confluent caseous necrosis (HE 25x)
Image 19a
Image 19b:  granuloma with caseous and cellular necrosis (HE 50x)
Image 19b
Image 19c:  granuloma with minute cellular necrosis and giant cells (HE 100x)
Image 19c
Image 19d:  granuloma with cellular (pseudotuberculoid) necrosis and giant cells (HE 100x)
Image 19d
Image 19e:  necrosis and Langhans-type giant cell (HE 200x)
Image 19e
Image 19f:  non-Langhans giant cell (HE 200x)
Image 19f
Image 19g:  necrosis and perinecrotic non-Langhans giant cells (HE 200x)
Image 19g

PCR status = negative

Image 19a: prostate with confluent caseous necrosis (HE 25x)
Image 19b: granuloma with caseous and cellular necrosis (HE 50x)
Image 19c: granuloma with minute cellular necrosis and giant cells (HE 100x)
Image 19d: granuloma with cellular (pseudotuberculoid) necrosis and giant cells (HE 100x)
Image 19e: necrosis and Langhans-type giant cell (HE 200x)
Image 19f: non-Langhans giant cell (HE 200x)
Image 19g: necrosis and perinecrotic non-Langhans giant cells (HE 200x)

Case 20

Image 20a:  lung with unspecific general inflammation, negative control, HOPE-fixation (HE 25x)
Image 20a
Image 20b: lung with unspecific general inflammation, negative control, HOPE-fixation (HE 50x)
Image 20b
Image 20c: lung with unspecific general inflammation, negative control, HOPE-fixation (HE 100x)
Image 20c

PCR status = negative

Image 20a: lung with unspecific general inflammation, negative control, HOPE-fixation (HE 25x)
Image 20b: lung with unspecific general inflammation, negative control, HOPE-fixation (HE 50x)
Image 20c: lung with unspecific general inflammation, negative control, HOPE-fixation (HE 100x)

Case 21

Image 21a:  lung with fibrosis/sclerosis (HE 25x)
Image 21a
Image 21b: lung with hemorrhage, caseous necrosis, strong perinecrotic sclerosis with focal calcification (HE 25x)
Image 21b
Image 21c:  hemorrhage, caseous necrosis (HE 50x)
Image 21c
Image 21d:  necrosis (HE 100x)
Image 21d

PCR status = negative

Image 21a: lung with fibrosis/sclerosis (HE 25x)
Image 21b: lung with hemorrhage, caseous necrosis, strong perinecrotic sclerosis with focal calcification (HE 25x)
Image 21c: hemorrhage, caseous necrosis (HE 50x)
Image 21d: necrosis (HE 100x)

Case 22

Image 22a:  lung with xanthomatoid inflammation around squamous cell carcinoma, negative control (HE 25x)
Image 22a
Image 22b:  lung squamous cell carcinoma (HE 25x)
Image 22b
Image 22c: lung squamous cell carcinoma (HE 100x)
Image 22c

PCR status = negative

Image 22a: lung with xanthomatoid inflammation around squamous cell carcinoma, negative control (HE 25x)
Image 22b: lung squamous cell carcinoma (HE 25x)
Image 22c: lung squamous cell carcinoma (HE 100x)

Case 23

Image 23a:  confluent necrosis and skeletal muscle, pleura/diaphragma (HE 25x)
Image 23a
Image 23b:  caseous necrosis with Langhans giant cell (HE 100x)
Image 23b
Image 23c: caseous granuloma (HE 200x)
Image 23c

PCR status = positive

Image 23a: confluent necrosis and skeletal muscle, pleura/diaphragma (HE 25x)
Image 23b: caseous necrosis with Langhans giant cell (HE 100x)
Image 23c: caseous granuloma (HE 200x)

Case 24

Image 24a:  strong (>50%, score 4) caseous necrosis, diaphragma (HE 25x)
Image 24a
Image 24b:  caseous necrosis with little inflammatory reaction (HE 50x)
Image 24b
Image 24c:  caseous necrosis with little inflammatory reaction (HE 100x)
Image 24c
Image 24d:  caseous necrosis with little inflammatory reaction (HE 100x)
Image 24d

PCR status = positive

Image 24a: strong (>50%, score 4) caseous necrosis, diaphragma (HE 25x)
Image 24b: caseous necrosis with little inflammatory reaction (HE 50x)
Image 24c: caseous necrosis with little inflammatory reaction (HE 100x)
Image 24d: caseous necrosis with little inflammatory reaction (HE 100x)

Case 25

Image 25a:  vertebral bone with caseous necrosis (HE 25x)
Image 25a
Image 25b:  vertebral bone with confluent caseous necrosis (HE 50x)
Image 25b
Image 25c:  necrosis with little inflammatory reaction (HE 100x)
Image 25c
Image 25d: necrosis with little inflammatory reaction (HE 200x)
Image 25d
Image 25e:  necrosis with little inflammatory reaction (HE 200x)
Image 25e

PCR status = positive

Image 25a: vertebral bone with caseous necrosis (HE 25x)
Image 25b: vertebral bone with confluent caseous necrosis (HE 50x)
Image 25c: necrosis with little inflammatory reaction (HE 100x)
Image 25d: necrosis with little inflammatory reaction (HE 200x)
Image 25e: necrosis with little inflammatory reaction (HE 200x)

Case 26

Image 26a: serous cysts (HE 25x)
Image 26a
Image 26b: inflammed tissue (probably in former lymph node) with confluent caseous necrosis (HE 25x)
Image 26b
Image 26c:  confluent (score 3) caseous necrosis with giant cell (HE 50x)
Image 26c
Image 26d:  Langhans and non-Langhans giant cells (HE 100x)
Image 26d
Image 26e:  non-caseous granuloma (HE 200x)
Image 26e

PCR status = positive

Image 26a: serous cysts (HE 25x)
Image 26b: inflammed tissue (probably in former lymph node) with confluent caseous necrosis (HE 25x)
Image 26c: confluent (score 3) caseous necrosis with giant cell (HE 50x)
Image 26d: Langhans and non-Langhans giant cells (HE 100x)
Image 26e: non-caseous granuloma (HE 200x)

Case 27

Image 27a: strong (score 4) caseos necrosis, lung (HE 50x)
Image 27a
Image 27b: caseous necrosis and medium (score 2) perinecrotic inflammation (HE 100x)
Image 27b
Image 27c: inflammatory infiltrate (HE 200x)
Image 27c
Image 27d: necrosis (HE 200x)
Image 27d

PCR status = positive

Image 27a: strong (score 4) caseos necrosis, lung (HE 50x)
Image 27b: caseous necrosis and medium (score 2) perinecrotic inflammation (HE 100x)
Image 27c: inflammatory infiltrate (HE 200x)
Image 27d: necrosis (HE 200x)

Case 28

Image 28a:  epididymis with low to medium (score 3) necrosis (HE 25x)
Image 28a
Image 28b:  necrosis with giant cells (HE 50x)
Image 28b
Image 28c: granuloma with caseous necrosis (HE 100x)
Image 28c
Image 28d:  granuloma with cellular (pseuodtuberculoid) necrosis (HE 100x)
Image 28d
Image 28e:  cellular necrosis with non-Langhans giant cell (HE 200x)
Image 28e
Image 28f:  Langhans giant cell (HE 400x)
Image 28f
Image 28g:  non-caseous granuloma (HE 100x)
Image 28g

PCR status = positive

Image 28a: epididymis with low to medium (score 3) necrosis (HE 25x)
Image 28b: necrosis with giant cells (HE 50x)
Image 28c: granuloma with caseous necrosis (HE 100x)
Image 28d: granuloma with cellular (pseuodtuberculoid) necrosis (HE 100x)
Image 28e: cellular necrosis with non-Langhans giant cell (HE 200x)
Image 28f: Langhans giant cell (HE 400x)
Image 28g: non-caseous granuloma (HE 100x)

Case 29

Image 29a:  prostate with necrosis (HE 25x)
Image 29a
Image 29b:  granuloma with caseous necrosis (HE 50x)
Image 29b
Image 29c: caseous necrosis (HE 100x)
Image 29c
Image 29d: non Langhans giant cell (HE 100x)
Image 29d
Image 29e: granuloma with caseous necrosis (HE 100x)
Image 29e

PCR status = negative

Image 29a: prostate with necrosis (HE 25x)
Image 29b: granuloma with caseous necrosis (HE 50x)
Image 29c: caseous necrosis (HE 100x)
Image 29d: non Langhans giant cell (HE 100x)
Image 29e: granuloma with caseous necrosis (HE 100x)

Case 30

Image 30a: Pleuritis (HE 25x)
Image 30a
Image 30b: chronic granulation with fibrinoid (caseous) necrosis (HE 100x)
Image 30b
Image 30c: necrosis (HE 100x)
Image 30c

PCR status = negative

Image 30a: Pleuritis (HE 25x)
Image 30b: chronic granulation with fibrinoid (caseous) necrosis (HE 100x)
mage 30c: necrosis (HE 100x)

Case 31

Image 31a:  peribronchial lung biopsy with granulomatous inflammation (HE 50x)
Image 31a
Image 31b: granuloma with minimal/punctuate (score 1) caseous necrosis (HE 100x)
Image 31b
Image 31c: granuloma with Langhans and non-Langhans giant cells (HE 100x)
Image 31c
Image 31d: non Langhans giant cell (HE 400x)
Image 31d

PCR status = negative

Image 31a: peribronchial lung biopsy with granulomatous inflammation (HE 50x)
Image 31b: granuloma with minimal/punctuate (score 1) caseous necrosis (HE 100x)
Image 31c: granuloma with Langhans and non-Langhans giant cells (HE 100x)
Image 31d: non Langhans giant cell (HE 400x)

Case 32

Image 32a: Epididymis with inflammation and necrosis (HE 25x)
Image 32a
Image 32b: confluent caseous necrosis (HE 50x)
Image 32b
Image 32c: cellular (pseudotuberculoid) necrosis (HE 50x)
Image 32c
Image 32d: Langhans giant cell (HE 200x)
Image 32d
Image 32e: non-Langhans giant cell (HE 200x)
Image 32e

PCR status = positive

Image 32a: Epididymis with inflammation and necrosis (HE 25x)
Image 32b: confluent caseous necrosis (HE 50x)
Image 32c: cellular (pseudotuberculoid) necrosis (HE 50x)
Image 32d: Langhans giant cell (HE 200x)
Image 32e: non-Langhans giant cell (HE 200x)

Case 33

Image 33a: mouse lung with inflammation, positive control (HE 50x)
Image 33a
Image 33b: mouse lung with inflammation, positive control (HE 100x)
Image 33b
Image 33c: inflammatory infiltrate (HE 200x)
Image 33c
Image 33d: inflammatory infiltrate (HE 200x)
Image 33d

PCR status = positive

Image 33a: mouse lung with inflammation, positive control (HE 50x)
Image 33b: mouse lung with inflammation, positive control (HE 100x)
Image 33c: inflammatory infiltrate (HE 200x)
Image 33d: inflammatory infiltrate (HE 200x)

Case 34

Image 34a: mouse lung with inflammation, positive control (HE 25x)
Image 34a
Image 34b: mouse lung with inflammation, positive control (HE 100x)
Image 34b
Image 34c: inflammatory infiltrate (HE 200x)
Image 34c
Image 34d: inflammatory infiltrate (HE 100x)
Image 34d

PCR status = positive

Image 34a: mouse lung with inflammation, positive control (HE 25x)
Image 34b: mouse lung with inflammation, positive control (HE 100x)
Image 34c: inflammatory infiltrate (HE 200x)
Image 34d: inflammatory infiltrate (HE 100x)