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Publications 2020
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- Authors:Arnold A, Tronser M, Sers C, Ahadova A, Endris V, Mamlouk S, Horst D, Möbs M, Bischoff P, Kloor M, Bläker H.
Journal:BMC Cancer. Year:2020 Oct 28; Volume:20Issue:(1):Pages:1038.
Title:The majority of β-catenin mutations in colorectal cancer is homozygous - Authors:Klotz-Noack K, Klinger B, Rivera M, Bublitz N, Uhlitz F, Riemer P, Lüthen M, Sell T, Kasack K, Gastl B, Ispasanie S, Simon T, Janssen N, Schwab M, Zuber J, Horst D, Blüthgen N, Schäfer R, Morkel M, Sers C.
Journal:Cell Rep. Year:2020 Sep 22; Volume:32Issue:(12):Pages:108184.
Title: SFPQ Depletion Is Synthetically Lethal with BRAF V600E in Colorectal Cancer Cells - Authors:Mamlouk S, Simon T, Tomás L, Wedge DC, Arnold A, Menne A, Horst D, Capper D, Morkel M, Posada D, Sers C, Bläker H.
Journal:BMC Biol. Year:2020 Sep 7; Volume:18Issue:(1):Pages:116.
Title:Malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression. - Authors:Gastl B, Klotz-Noack K, Klinger B, Ispasanie S, Salib KHF, Zuber J, Mamlouk S, Bublitz N, Blüthgen N, Horst D, Morkel M, Schäfer R, Sers C.
Journal:Cell Death Dis. Year:2020 Jul 1; Volume:11Issue:(7):Pages:499.
Title:Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe. - Authors:Ozkan-Dagliyan I, Diehl JN, George SD, Schaefer A, Papke B, Klotz-Noack K, Waters AM, Goodwin CM, Gautam P, Pierobon M, Peng S, Gilbert TSK, Lin KH, Dagliyan O, Wennerberg K, Petricoin EF 3rd, Tran NL, Bhagwat SV, Tiu RV, Peng SB, Herring LE, Graves LM, Sers C, Wood KC, Cox AD, Der CJ.
Journal:Cell Rep. Year:2020 Jun 16; Volume:31Issue:(11):Pages:107764.
Title:Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers - Authors:Lamping M, Benary M, Leyvraz S, Messerschmidt C, Blanc E, Kessler T, Schütte M, Lenze D, Jöhrens K, Burock S, Klinghammer K, Ochsenreither S, Sers C, Schäfer R, Tinhofer I, Beule D, Klauschen F, Yaspo ML, Keilholz U, Rieke DT.
Journal:Eur J Cancer. Year:2020 March; :Pages:127:41-51.
Title: Support of a molecular tumour board by an evidence-based decision management system for precision oncology
Publications 2019
Authors:Brandt R, Sell T, Lüthen M, Uhlitz F, Klinger B, Riemer P, Giesecke-Thiel C, Schulze S, El-Shimy IA, Kunkel D, Fauler B, Mielke T, Mages N, Herrmann BG, Sers C, Blüthgen N, Morkel M.
Title:Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium.
Journal:Nat Commun Year:2019; Volume:10Issue:(1)
Authors:Schulz GB, Grimm T, Sers C, Riemer P, Elmasry M, Kirchner T, Stief CG, Karl A, Horst D.
Title:Prognostic value and association with epithelial-mesenchymal transition and molecular subtypes of the proteoglycan biglycan in advanced bladder cancer.
Journal:Urol Oncol Year:2019; Volume:37Issue:(8):Pages:530.
Authors:Voglstaetter M, Thomsen AR, Nouvel J, Koch A, Jank P, Navarro EG, Gainey-Schleicher T, Khanduri R, Groß A, Rossner F, Blaue C, Franz CM, Veil M, Puetz G, Hippe A, Dindorf J, Kashef J, Thiele W, Homey B, Greco C, Boucheix C, Baur A, Erbes T, Waller CF, Follo M, Hossein G, Sers C, Sleeman J, Nazarenko I.
Title:Tspan8 is expressed in breast cancer and regulates E-cadherin/catenin signalling and metastasis accompanied by increased circulating extracellular vesicles.
Journal:J Pathol Year:2019; Volume:248Issue:(4):Pages:421-437.
Authors:Loibl S, Treue D, Budczies J, Weber K, Stenzinger A, Schmitt WD, Weichert W, Jank P, Furlanetto J, Klauschen F, Karn T, Pfarr N, von Minckwitz G, Möbs M, Jackisch C, Sers C, Schneeweiss A, Fasching PA, Schem C, Hummel M, van Mackelenbergh M, Nekljudova V, Untch M, Denkert C.
Title:Mutational Diversity and Therapy Response in Breast Cancer: A Sequencing Analysis in the Neoadjuvant GeparSepto Trial.
Journal:Clin Cancer Res Year:2019; Volume:25Issue:(13):Pages:3986-3995.
Authors:Heberle AM, Razquin Navas P, Langelaar-Makkinje M, Kasack K, Sadik A, Faessler E, Hahn U, Marx-Stoelting P, Opitz CA, Sers C, Heiland I, Schäuble S, Thedieck K.
Title:The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner.
Journal:Life Sci Alliance Year:2019; Volume:2Issue:(2)
Authors:Jurmeister P, Schöler A, Arnold A, Klauschen F, Lenze D, Hummel M, Schweizer L, Bläker H, Pfitzner BM, Mamlouk S, Sers C, Denkert C, Stichel D, Frost N, Horst D, von Laffert M, Capper D.
Title:DNA methylation profiling reliably distinguishes pulmonary enteric adenocarcinoma from metastatic colorectal cancer.
Journal:Mod Pathol Year:2019; Volume:32Issue:(6):Pages:855-865.
Authors:Otto R, Rössler JN, Sers C, Mamlouk S, Leser U.
Title:Robust in-silico identification of Cancer Cell Lines based on RNA and targeted DNA sequencing data.
Journal:Sci Rep Year:2019; Volume:9Issue:(1):Pages:367.
Authors:Bormann, F., Stinzing, S., Tierling, S., Morkel, M., Markelova, M.R., Walter, J., Weichert, W., Roßner, F., Kuhn, N., Perner, J., Dietz, J., Ispasanie, S., Dietel, M., Schäfer, R., Heinemann, V., Sers, C.
Title:Epigenetic regulation of Amphiregulin and Epiregulin in colorectal cancer.
Journal:Int J Cancer Year:2019; Volume:144Issue:(3):Pages:569-581.
Authors:Starossom, S.C., Campo Garcia, J., Woelfle, T., Romero-Suarez, S., Olah, M., Watanabe, F., Cao, L., Yeste, A., Tukker, J.J., Quintana, F.J., Imitola, J., Witzel, F., Schmitz, D., Morkel, M., Paul, F., Infante-Duarte, C., Khoury, S.J.
Title:Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation.
Journal:Nat Commun Year:2019; Volume:10Issue:(1):Pages:217.
Authors:Rohwer, N., Jumpertz, S., Erdem, M., Egners, A., Warzecha, K.T., Fragoulis, A., Kühl, A.A., Kramann, R., Neuss, S., Rudolph, I., Endermann, T., Zasada, C., Apostolova, I., Gerling, M., Kempa, S., Hughes, R., Lewis, C.E., Brenner, W., Malinowski, M.B., Stockmann, M., Schomburg, L., Faller, W., Sansom, O.J., Tacke, F., Morkel, M., Cramer, T.
Title:Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis.
Journal:Oncogene Year:2019; Volume:38Issue:(28):Pages:5670-5685.
Publications 2018
Authors:Starlinger J, Pallarz S, Ševa J, Rieke D, Sers C, Keilholz U, Leser U
Title:Variant information systems for precision oncology.
Journal:BMC Med Inform Decis Mak Year:2018; Volume:18Issue:(1):Pages:107.
Authors:Thobe K, Kuznia C, Sers C, Siebert H
Title:Evaluating Uncertainty in Signaling Networks Using Logical Modeling.
Journal:Front Physiol Year:2018; Volume:9:Pages:1335.
Authors:Bormann F, Stinzing S, Tierling S, Morkel M, Markelova MR, Walter J, Weichert W, Roßner F, Kuhn N, Perner J, Dietz J, Ispasanie S, Dietel M, Schäfer R, Heinemann V, Sers C
Title:Epigenetic regulation of Amphiregulin and Epiregulin in colorectal cancer.
Journal:Int J Cancer Year:Epub 2018; Volume:144Issue:(3):Pages:569-581.
Authors:Tiwari A, Rebholz S, Maier E, Dehghan Harati M, Zips D, Sers C, Rodemann HP, Toulany M
Title:Stress-Induced Phosphorylation of Nuclear YB-1 Depends on Nuclear Trafficking of p90 Ribosomal S6 Kinase.
Journal:Int J Mol Sci Year:2018; Volume:19Issue:(8):Pages:pii: E2441.
Authors:Fritsche-Guenther R, Zasada C, Mastrobuoni G, Royla N, Rainer R, Roßner F, Pietzke M, Klipp E, Sers C, Kempa S
Title:Alterations of mTOR signaling impact metabolic stress resistance in colorectal carcinomas with BRAF and KRAS mutations.
Journal:Sci Rep Year:2018; Volume:8Issue:(1):Pages:9204.
Publications 2017
Authors:Thobe K, Sers C, Siebert H
Title:Unraveling the regulation of mTORC2 using logical modeling
Journal:Cell Commun Signal Year:2017; Volume:15(1)Issue:(6)
Authors:Mamlouk, S., Childs, L.H., Aust, D., Melching, F., Wolf, T., Oliveira, C., Durek, P., Schumacher, D., Bläker, H., von Winterfeld, M., Schäfer, R., Klauschen, F., Gastl, B., Heim, D., Möhr, K., Menne, A., Redmer, T., Lenze, D., Tierling, S., Morkel, M., Möbs, M., Weichert, W., Folprecht, G., Leser, U., and Sers, C.
Title:DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer
Journal:Nat Commun Year:2017; Volume:8:Pages:14093.
Authors:Riemer P, Rydenfelt M, Marks M, van Eunen K, Thedieck K, Herrmann BG, Blüthgen N, Sers C, Morkel M
Title:Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids
Journal:J Cell Biol Year:2017; Volume:216Issue:(6):Pages:1567-1577.
Authors:Otto R, Sers C, Leser U
Title:Robust in-silico identification of cancer cell lines based on next generation sequencing
Journal:Oncotarget Year:2017; Volume:8Issue:(21):Pages:34310-34320.
Publications 2016
Authors:Roßner F, Gieseler C, Morkel M, Royer HD, Rivera M, Bläker H, Dietel M, Schäfer R, Sers C
Title:Uncoupling of EGFR-RAS signaling and nuclear localization of YBX1 in colorectal cancer
Journal:Oncogenesis Year:2016 Jan 18; Volume:5:Pages:e187.
Authors:Fritsche-Guenther R, Witzel F, Kempa S, Brummer T, Sers C, Blüthgen N
Title:Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis
Journal:Oncotarget Year:2016 Feb 16; Volume:7Issue:(7):Pages:7960-9.
Authors:Childs LH, Mamlouk S, Brandt J, Sers C, Leser U
Title:SoFIA: a data integration framework for annotating high-throughput datasets
Journal:Bioinformatics Year:2016; Volume:32Issue:(17):Pages:2590-7.
Authors:Möller Y, Morkel M, Schmid J, Beyes S, Hendrick J, Strotbek M, Riemer P, Schmid S, Schmitt LC, Kontermann R, Mürdter T, Schwab M, Sers C, Olayioye MA
Title:Oncogenic Ras triggers hyperproliferation and impairs polarized colonic morphogenesis by autocrine ErbB3 signaling
Journal:Oncotarget Year:2016; Volume:7Issue:(33):Pages:53526-53539.
Authors:Pavel ME, Sers C
Title:WOMEN IN CANCER THEMATIC REVIEW: Systemic therapies in neuroendocrine tumors and novel approaches toward personalized medicine
Journal:Endocr Relat Cancer Year:2016; Volume:23Issue:(11):Pages:T135-T154.
Publications 2015
Authors:Györffy B, Stelniec-Klotz I, Sigler C, Kasack K, Redmer T, Qian Y, Schäfer R.
Title:Effects of RAL signal transduction in KRAS- and BRAF-mutated cells and prognostic potential of the RAL signature in colorectal cancer.
Journal:Oncotarget. Year:2015;
Authors:Jesinghaus M, Wolf T, Pfarr N, Muckenhuber A, Ahadova A, Warth A, Goeppert B, Sers C, Kloor M, Endris V, Stenzinger A, Weichert W.
Title:Distinctive Spatiotemporal Stability of Somatic Mutations in Metastasized Microsatellite-stable Colorectal Cancer.
Journal:Am J Surg Pathol Year:2015; Volume:[Epub ahead of print]
Authors:Jurmeister P, Lenze D, Berg E, Mende S, Schäper F, Kellner U, Herbst H, Sers C, Budczies J, Dietel M, Hummel M, von Laffert M
Title:Parallel screening for ALK, MET and ROS1 alterations in non-small cell lung cancer with implications for daily routine testing
Journal:Lung Cancer Year:2015; Volume:87Issue:(2):Pages:122-9.
Authors:Dietel M, Jöhrens K, Laffert MV, Hummel M, Bläker H, Pfitzner BM, Lehmann A, Denkert C, Darb-Esfahani S1, Lenze D, Heppner FL, Koch A, Sers C, Klauschen F, Anagnostopoulos I
Title:A 2015 update on predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance
Journal:Cancer Gene Ther Year:2015; Volume:22Issue:(9):Pages:417-30.
Authors:Morkel M, Riemer P, Bläker H, Sers C
Title:Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance
Journal:Oncotarget Year:2015; Volume:6Issue:(25):Pages:20785-800.
Publications 2014
- Authors:Lienhard M, Grimm C, Morkel M, Herwig R, Chavez L
Journal:Bioinformatics Year:2014; Volume:30Issue:(2):Pages:284-6.
Title:MEDIPS: genome-wide differential coverage analysis of sequencing data derived from DNA enrichment experiments - Authors:Redmer T, Welte Y, Behrens D, Fichtner I, Przybilla D, Wruck W, Yaspo ML, Lehrach H, Schäfer R, Regenbrecht CR.
Journal:PLoS One Year:2014; Volume:9Issue:(5):Pages:e92596.
Title:The nerve growth factor receptor CD271 is crucial to maintain tumorigenicity and stem-like properties of melanoma cells.
Publications 2013
- Authors:Dietel M, Jöhrens K, Laffert M, Hummel M, Bläker H, Müller BM, Lehmann A, Denkert C, Heppner FL, Koch A, Sers C, Anagnostopoulos I
Journal:Cancer Gene Ther Year:2013; Volume:20Issue:(4):Pages:211-21.
Title:Predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance - Authors:Gries J, Schumacher D, Arand J, Lutsik P, Markelova MR, Fichtner I, Walter J, Sers C, Tierling S.
Journal:Epigenetics Year:2013; Volume:8Issue:(7):Pages:765-71.
Title:Bi-PROF: bisulfite profiling of target regions using 454 GS FLX Titanium technology - Authors:Welte Y, Davies C, Schäfer R, Regenbrecht CR
Journal:J Vis Exp. Year:2013; Volume:73:Pages:e50200.
Title:Patient derived cell culture and isolation of CD133⁺ putative cancer stem cells from melanoma. - Authors:Pénzváltó Z, Tegze B, Szász AM, Sztupinszki Z, Likó I, Szendrői A, Schäfer R, Győrffy B.
Journal:PLoS One. Year:2013; Volume:8Issue:(3):Pages:e59503.
Title:Identifying resistance mechanisms against five tyrosine kinase inhibitors targeting the ERBB/RAS pathway in 45 cancer cell lines. - Authors:Malek A, Gyorffy B, Catapano CV, Schäfer R
Journal:Cancer Gene Ther. Year:2013; Volume:20Issue:(5):Pages:326-9.
Title:Selection of optimal combinations of target genes for therapeutic multi-gene silencing based on miRNA co-regulation.
Publications 2012
- Authors:Győrffy B, Benke Z, Lánczky A, Balázs B, Szállási Z, Timár J, Schäfer R.
Journal:Breast Cancer Res Treat. Year:2012; Volume:132Issue:(3):Pages:1025-34.
Title:RecurrenceOnline: an online analysis tool to determine breast cancer recurrence and hormone receptor status using microarray data.
Publications 2011
- Authors:Schäfer R, Sers C.
Journal:Adv Enzyme Regul. Year:2011; Volume:51Issue:(1):Pages:126-36.
Title:RAS oncogene-mediated deregulation of the transcriptome: From molecular signature to function
Publications 2010
- Authors:Tchernitsa O, Kasajima A, Schäfer R, Kuban RJ, Ungethüm U, Györffy B, Neumann U, Simon E, Weichert W, Ebert MP, Röcken C.
Journal:J Pathol. Year:2010; Volume:222Issue:(2):Pages:10-9.
Title:Systematic evaluation of the miRNA-ome and its downstream effects on mRNA expression identifies gastric cancer progression - Authors:Krech T, Thiede M, Hilgenberg E, Schäfer R and Jürchott K.
Journal:BMC Cancer Year:2010; Volume:10:Pages:287.
Title:Characterization of AKT independent effects of the synthetic AKT inhibitors SH-5 and SH-6 using an integrated approach combining transcriptomic profiling and signalling pathway pertubations - Authors:Munkácsy G, Abdul-Ghani R, Mihály Z, Tegze B, Tchernitsa O, Surowiak P, Schäfer R, Györffy B.
Journal:Br J Cancer Year:2010; Volume:102Issue:(2):Pages:361-8.
Title:PSMB7 is associated with anthracycline resistance and is a prognostic biomarker in breast cancer - Authors:Nazarenko I, Jenny M, Gieseler C, Weisshaupt K, Sehouli J, Legewie S, Herbst L, Weichert W, Darb-Esfahani S, Dietel M, Schäfer R, Ueberall F, Sers C.
Journal:FEBS J Year:2010; Volume:8Issue:(6):Pages:913-934.
Title:Atypical protein kinase C zeta exhibits a pro-apoptotic function in ovarian cancer - Authors:Wolkenhauer O, Auffray C, Baltrusch B, Blüthgen N, Byrne H, Cascante M,
Ciliberto A, Dale T, Drasdo D, Fell D, Ferrell JEJr., Gallahan D, Gatenby R, Günther U, Harms BD, Herzel H, Junghanss C, Kunz M, van Leeuwen I, Lenormand P, Levi F, Linnebacher M, Lowengrub J, Maini PK, Malik A, Rateitschak K, Sansom O, Schäfer R, Schürrle K, Sers C, Schnell S, Shibata D, Tyson J, Vera J, White M, Zhivotovsky B, and Jaster R.
Journal:Cancer Res. Year:2010; Volume:70Issue:(1):Pages:12-3.
Title:Systems biologists seek fuller integration of systems biology approaches in new cancer research programs - Authors:Györffy B, Schäfer R.
Journal:BMC Cancer Year:2010; Volume:10Issue:(8):Pages:858-68.
Title:Biomarkers downstream of RAS: A search for robust transcriptional targets - Authors:Jürchott K, Kuban RJ, Krech T, Blüthgen N, Stein U, Walther W, Friese C, Kiełbasa SM, Ungethüm U, Lund P, Knösel T, Kemmner W, Morkel M, Fritzmann J, Schlag PM, Birchmeier W, Krueger T, Sperling S, Sers C, Royer HD, Herzel H, Schäfer R.
Journal:PLoS Genet. Year:2010; Volume:6Issue:(12):Pages:e1001231.
Title:Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway- dependent gene signatures in colorectal cancer cells
Publications 2009
- Authors:Blüthgen N, Legewie S, Kielbasa SM, Schramme A, Tchernitsa O, Keil J, Solf A, Vingron M, Schäfer R, Herzel H, Sers C.
Journal:FEBS J Year:2009; Volume:276Issue:(4):Pages:1024-35.
Title:A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts - Authors:Sers C, Kuner R, Falk CS, Lund P, Sueltmann H, Braun M, Buness A, Ruschhaupt M, Conrad J, Mang-Fatehi S, Stelniec I, Krapfenbauer U, Poustka A, Schäfer R.
Journal:Int J Cancer Year:2009; Volume:125Issue:(7):Pages:1626-39.
Title:Down-regulation of HLA Class I and NKG2D ligands through a concerted action of MAPK and DNA methyltransferases in colorectal cancer cells
Publications 2008
- Authors:Malek A, Bakhidze E, Noske A, Sers C, Aigner A, Schäfer R, Tchernitsa O.
Journal:Int J Cancer Year:2008; Volume:123Issue:(2):Pages:348-56.
Title:HMGA2 gene is a promising target for ovarian cancer silencing therapy
Publications 2007
- Authors:Schäfer R, Schramme A, Tchernitsa OI, Sers C.
Journal:Recent Results Cancer Res. Year:2007; Volume:176Issue:(7):Pages:24.
Title:Oncogenic signaling pathways and deregulated target genes - Authors:Nazarenko I, Schäfer R, Sers C.
Journal:J Cell Sci Year:2007; Volume:120Issue:(8):Pages:1393-404.
Title:Mechanisms of the HRSL3 tumor suppressor function in ovarian carcinoma cells
Publications 2006
- Authors:Lund P, Weisshaupt K, Mikeska T, Jammas D, Chen X, Kuban RJ, Ungethüm U, Krapfenbauer U, Herzel HP, Schäfer R, Walter J, Sers C.
Journal:Oncogene Year:2006; Volume:25Issue:(35):Pages:4890-903.
Title:Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation.
Publications 2005
- Authors:Lotz K, Kellner T, Heitmann M, Nazarenko I, Noske A, Malek A, Gontarewicz A, Schäfer R, Sers C.
Journal:Int J Cancer Year:2005; Volume:116Issue:(6):Pages:894-902.
Title:Suppression of the TIG3 tumor suppressor gene in human ovarian carcinomas is mediated via mitogen-activated kinase-dependent and -independent mechanisms
Publications 2004
- Authors:Tchernitsa OI, Sers C, Zuber J, Hinzmann B, Grips M, Schramme A, Lund P, Schwendel A, Rosenthal A, Schäfer R.
Journal:Oncogene Year:2004; Volume:23Issue:(26):Pages:4536-55.
Title:Transcriptional basis of KRAS oncogene-mediated cellular transformation in ovarian epithelial cells
Publications 2002
- Authors:Sers C, Husmann K, Nazarenko I, Reich S, Wiechen K, Zhumabayeva B, Adhikari P, Schröder K, Gontarewicz A, Schäfer R.
Journal:Oncogene Year:2002; Volume:25Issue:(21):Pages:2829-39.
Title:The class II tumour suppressor gene H-REV107-1 is a target of interferon-regulatory factor-1 and is involved in IFNgamma-induced cell death in human ovarian carcinoma cells
Publications 2000
- Authors:Zuber J, Tchernitsa OI, Hinzmann B, Schmitz AC, Grips M, Hellriegel M, Sers C, Rosenthal A, Schäfer R.
Journal:Nat Genet Year:2000; Volume:24Issue:(2):Pages:144-52.
Title:A genome-wide survey of RAS transformation targets