Das Bild zeigt rechts ein Trichterglas mit blauer Flüssigkeit und Glasstab zum Umrühren. Daneben steht ein Reagenzglasständer mit Reagenzgläsern, die ebenfalls blaue Flüssigkeit enthalten. Im Hintergrund ist ein Forscher zu sehen, der in der rechten Hand eine Pipette hält.

Publikationen

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Publikationen

2010

Jet-injection of short hairpin RNA-encoding vectors into tumor cells.Walther W, Stein U, Lage H.Methods Mol Biol. 2010;629:123-39.PMID: 20387147

Antitumor activity of terpenoids against classical and atypical multidrug resistant cancer cells. Lage H, Duarte N, Coburger C, Hilgeroth A, Ferreira MJ. Phytomedicine. 2010 May;17(6):441-8. Epub 2009 Aug 13. PMID: 19682879

Phenolic Compounds as Selective Antineoplasic Agents against Multidrug-resistant Human Cancer Cells. Duarte N, Lage H, Abrantes M, José Ferreira MU. Planta Med. 2010 Feb 15. [Epub ahead of print] PMID: 20157880

Regulation of mRNA expression in drug-sensitive and drug-resistant gastric carcinoma cells is independent of YB-1 expression. Kurucz R, Belian E, Treue D, Lage H. Anticancer Res. 2010 Feb;30(2):693-8. PMID: 20332492

Effect of YB-1 on the regulation of micro RNA expression in drug-sensitive and drug-resistant gastric carcinoma cells.


2009

Positive correlation between cyclooxygenase-2 and ABC-transporter expression in non-Hodgkin's lymphomas. Szczuraszek K, Materna V, Halon A, Mazur G, Wróbel T, Kuliczkowski K, Maciejczyk A, Zabel M, Drag M, Dietel M, Lage H, Surowiak P. Oncol Rep. 2009 Dec;22(6):1315-23. PMID: 19885582

Delivery of short hairpin RNAs by transkingdom RNA interference modulates the classical ABCB1-mediated multidrug-resistant phenotype of cancer cells. Krühn A, Wang A, Fruehauf JH, Lage H. Cell Cycle. 2009 Oct 15;8(20):3349-54. Epub 2009 Oct 18. PMID: 19770582

Adenovirus-based virotherapy enabled by cellular YB-1 expression in vitro and in vivo. Rognoni E, Widmaier M, Haczek C, Mantwill K, Holzmüller R, Gansbacher B, Kolk A, Schuster T, Schmid RM, Saur D, Kaszubiak A, Lage H, Holm PS. Cancer Gene Ther. 2009 Oct;16(10):753-63. Epub 2009 Apr 10. PMID: 19363467

Interleukin-1 beta and tumor necrosis factor-alpha increase ABCG2 expression in MCF-7 breast carcinoma cell line and its mitoxantrone-resistant derivative, MCF-7/MX. Mosaffa F, Lage H, Afshari JT, Behravan J. Inflamm Res. 2009 Oct;58(10):669-76. Epub 2009 Mar 31. PMID: 19333723

Antitumor activity of terpenoids against classical and atypical multidrug resistant cancer cells. Lage H, Duarte N, Coburger C, Hilgeroth A, Ferreira MJ. Phytomedicine. 2009 Aug 13. [Epub ahead of print] PMID: 19682879

Influx and efflux transport as determinants of melphalan cytotoxicity: Resistance to melphalan in MDR1 overexpressing tumor cell lines. Kühne A, Tzvetkov MV, Hagos Y, Lage H, Burckhardt G, Brockmöller J. Biochem Pharmacol. 2009 Jul 1;78(1):45-53. Epub 2009 Apr 5. PMID: 19447222

A prognostic gene expression index in ovarian cancer - validation across different independent data sets. Denkert C, Budczies J, Darb-Esfahani S, Györffy B, Sehouli J, Könsgen D, Zeillinger R, Weichert W, Noske A, Buckendahl AC, Müller BM, Dietel M, Lage H. J Pathol. 2009 Jun;218(2):273-80. PMID: 19294737

Evaluation of microarray preprocessing algorithms based on concordance with RT-PCR in clinical samples. Gyorffy B, Molnar B, Lage H, Szallasi Z, Eklund AC. PLoS One. 2009 May 21;4(5):e5645. PMID: 19461970

Expression of multidrug resistance-associated protein 1 in invasive ovarian carcinoma: implication for prognosis. Faggad A, Darb-Esfahani S, Wirtz R, Sinn B, Sehouli J, Könsgen D, Lage H, Noske A, Weichert W, Buckendahl AC, Budczies J, Müller BM, Elwali NE, Dietel M, Denkert C. Histopathology. 2009 May;54(6):657-66. PMID: 19438741

Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug-resistant cell lines. Drag M, Surowiak P, Drag-Zalesinska M, Dietel M, Lage H, Oleksyszyn J. Molecules. 2009 Apr 24;14(4):1639-51. PMID: 19396022

Topoisomerase IIalpha mRNA and protein expression in ovarian carcinoma: correlation with clinicopathological factors and prognosis. Faggad A, Darb-Esfahani S, Wirtz R, Sinn B, Sehouli J, Könsgen D, Lage H, Weichert W, Noske A, Budczies J, Müller BM, Buckendahl AC, Röske A, Eldin Elwali N, Dietel M, Denkert C. Mod Pathol. 2009 Apr;22(4):579-88. Epub 2009 Mar 6. PMID: 19270648 

Therapeutic potential of RNA interference in drug-resistant cancers. Lage H. Future Oncol. 2009 Mar;5(2):169-85. Review. PMID: 19284376

Impact of novel MDR modulators on human cancer cells: reversal activities and induction studies. Coburger C, Lage H, Molnár J, Hilgeroth A. Pharm Res. 2009 Jan;26(1):182-8. Epub 2008 Oct 30. PMID: 18972190


2008

Acquired cisplatin resistance in the head-neck cancer cell line Cal27 is associated with decreased DKK1 expression and can partially be reversed by overexpression of DKK1. Gosepath EM, Eckstein N, Hamacher A, Servan K, von Jonquieres G, Lage H, Györffy B, Royer HD, Kassack MU. Int J Cancer. 2008 Nov 1;123(9):2013-9. PMID: 18688867

A snapshot of microarray-generated gene expression signatures associated with ovarian carcinoma. Györffy B, Dietel M, Fekete T, Lage H. Int J Gynecol Cancer. 2008 Nov-Dec;18(6):1215-33. Epub 2008 Jan 22. PMID: 18217975

[YB-1 as a potential target in cancer therapy] Lage H, Surowiak P, Holm PS. Pathologe. 2008 Nov;29 Suppl 2:187-90. Review. German. PMID: 18773210

An overview of cancer multidrug resistance: a still unsolved problem. Lage H. Cell Mol Life Sci. 2008 Oct;65(20):3145-67. Review. PMID: 18581055

Novel insight in structure-activity relationship and bioanalysis of P-glycoprotein targeting highly potent tetrakishydroxymethyl substituted 3,9-diazatetraasteranes. Coburger C, Wollmann J, Baumert C, Krug M, Molnár J, Lage H, Hilgeroth A. J Med Chem. 2008 Sep 25;51(18):5871-4. Epub 2008 Aug

Positive correlation between cyclooxygenase 2 and the expression of ABC transporters in non-small cell lung cancer. Surowiak P, Pawełczyk K, Maciejczyk A, Pudełko M, Kołodziej J, Zabel M, Murawa D, Drag M, Gansukh T, Dietel M, Lage H. Anticancer Res. 2008 Sep-Oct;28(5B):2967-74. PMID: 19031941

Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone. Hoffmann J, Vitale I, Buchmann B, Galluzzi L, Schwede W, Senovilla L, Skuballa W, Vivet S, Lichtner RB, Vicencio JM, Panaretakis T, Siemeister G, Lage H, Nanty L, Hammer S, Mittelstaedt K, Winsel S, Eschenbrenner J, Castedo M, Demarche C, Klar U, Kroemer G. Cancer Res. 2008 Jul 1;68(13):5301-8. PMID: 18593931

Decreased expression of p16 in ovarian cancers represents an unfavourable prognostic factor. Surowiak P, Materna V, Maciejczyk A, Pudelko M, Suchocki S, Kedzia W, Nowak-Markwitz E, Dumanska M, Spaczynski M, Zabel M, Dietel M, Lage H. Histol Histopathol. 2008 May;23(5):531-8. PMID: 18283637

Impact of radiation therapy on the oncolytic adenovirus dl520: implications on the treatment of glioblastoma. Bieler A, Mantwill K, Holzmüller R, Jürchott K, Kaszubiak A, Stärk S, Glockzin G, Lage H, Grosu AL, Gansbacher B, Holm PS. Radiother Oncol. 2008 Mar;86(3):419-27. Epub 2007 Oct 29. PMID: 17967494

Complete in vivo reversal of the multidrug resistance phenotype by jet-injection of anti-MDR1 short hairpin RNA-encoding plasmid DNA. Stein U, Walther W, Stege A, Kaszubiak A, Fichtner I, Lage H. Mol Ther. 2008 Jan;16(1):178-86. Epub 2007 Sep 18. PMID: 17878902

Estradiol, tamoxifen and ICI 182,780 alter alpha3 and beta1 integrin expression and laminin-1 adhesion in oral squamous cell carcinoma cell cultures. Nelson K, Helmstaedter V, Moreau C, Lage H. Oral Oncol. 2008 Jan;44(1):94-9. Epub 2007 Apr 5. PMID: 17418616

Three new jatrophane polyesters and antiproliferative constituents from Euphorbia tuckeyana. Duarte N, Lage H, Ferreira MJ. Planta Med. 2008 Jan;74(1):61-8. Epub 2008 Jan 4. PMID: 18176909


2007

Antineoplastic activity of 2-methoxyestradiol in human pancreatic and gastric cancer cells with different multidrug-resistant phenotypes. Schumacher G, Hoffmann J, Cramer T, Spinelli A, Jacob D, Bahra M, Pratschke J, Pfitzmann R, Schmidt S, Lage H. J Gastroenterol Hepatol. 2007 Sep;22(9):1469-73. Epub 2007 Jul 20. PMID: 17645459  

The gene polymorphism of the angiotensin I-converting enzyme correlates with tumor size and patient survival in colorectal cancer patients. Röcken C, Neumann K, Carl-McGrath S, Lage H, Ebert MP, Dierkes J, Jacobi CA, Kalmuk S, Neuhaus P, Neumann U. Neoplasia. 2007 Sep;9(9):716-22. PMID: 17898867 

Overcoming the classical multidrug resistance phenotype by adenoviral delivery of anti-MDR1 short hairpin RNAs and ribozymes. Kaszubiak A, Holm PS, Lage H. Int J Oncol. 2007 Aug;31(2):419-30. PMID: 17611700

The influence of tamoxifen on growth behavior and cell-cell adhesion in OSCC in vitro. Nelson K, Helmstaedter V, Lage H. Oral Oncol. 2007 Aug;43(7):720-7. Epub 2006 Nov 16. PMID: 17112777

Occurence of stromal myofibroblasts in the invasive ductal breast cancer tissue is an unfavourable prognostic factor. Surowiak P, Murawa D, Materna V, Maciejczyk A, Pudelko M, Ciesla S, Breborowicz J, Murawa P, Zabel M, Dietel M, Lage H. Anticancer Res. 2007 Jul-Aug;27(4C):2917-24. PMID: 17695471

Unfavourable prognostic significance of S100P expression in ovarian cancers. Surowiak P, Maciejczyk A, Materna V, Drag-Zalesińska M, Wojnar A, Pudelko M, Kedzia W, Spaczyński M, Dietel M, Zabel M, Lage H. Histopathology. 2007 Jul;51(1):125-8. Epub 2007 May 31. No abstract available. PMID: 17539915

Regulation of MDR1 gene expression in multidrug-resistant cancer cells is independent from YB-1. Kaszubiak A, Kupstat A, Müller U, Hausmann R, Holm PS, Lage H. Biochem Biophys Res Commun. 2007 May 25;357(1):295-301. Epub 2007 Apr 2. PMID: 17418094

Expression of factors involved in regulation of DNA mismatch repair- and apoptosis pathways in ovarian cancer patients. Materna V, Surowiak P, Markwitz E, Spaczynski M, Drag-Zalesinska M, Zabel M, Lage H. Oncol Rep. 2007 Mar;17(3):505-16. PMID: 17273726

Nuclear metallothionein expression correlates with cisplatin resistance of ovarian cancer cells and poor clinical outcome. Surowiak P, Materna V, Maciejczyk A, Pudełko M, Markwitz E, Spaczyński M, Dietel M, Zabel M, Lage H. Virchows Arch. 2007 Mar;450(3):279-85. Epub 2007 Jan 19. PMID: 17235562

Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation: increased expression of AKT in advanced ovarian cancer. Noske A, Kaszubiak A, Weichert W, Sers C, Niesporek S, Koch I, Schaefer B, Sehouli J, Dietel M, Lage H, Denkert C. Cancer Lett. 2007 Feb 8;246(1-2):190-200. Epub 2006 Apr 3. PMID: 16584837

A Web-based data warehouse on gene expression in human malignant melanoma. Györffy B, Lage H. J Invest Dermatol. 2007 Feb;127(2):394-9. Epub 2006 Aug 31. PMID: 16946712

Taxol-resistance-associated gene-3 (TRAG-3/CSAG2) expression is predictive for clinical outcome in ovarian carcinoma patients. Materna V, Surowiak P, Kaplenko I, Spaczyński M, Duan Z, Zabel M, Dietel M, Lage H. Virchows Arch. 2007 Feb;450(2):187-94. PMID: 17216190

Resistance to chemotherapy in ovarian carcinoma. Lage H, Denkert C. Recent Results Cancer Res. 2007;176:51-60. Review. PMID: 17607916


2006

ABCC2 (MRP2, cMOAT) can be localized in the nuclear membrane of ovarian carcinomas and correlates with resistance to cisplatin and clinical outcome. Surowiak P, Materna V, Kaplenko I, Spaczynski M, Dolinska-Krajewska B, Gebarowska E, Dietel M, Zabel M, Lage H. Clin Cancer Res. 2006 Dec 1;12(23):7149-58. PMID: 17145840

CD46 expression is indicative of shorter revival-free survival for ovarian cancer patients. Surowiak P, Materna V, Maciejczyk A, Kaplenko I, Spaczynski M, Dietel M, Lage H, Zabel M. Anticancer Res. 2006 Nov-Dec;26(6C):4943-8. PMID: 17214367

Complete reversal of ABCG2-depending atypical multidrug resistance by RNA interference in human carcinoma cells. Priebsch A, Rompe F, Tönnies H, Kowalski P, Surowiak P, Stege A, Materna V, Lage H. Oligonucleotides. 2006 Fall;16(3):263-74. PMID: 16978089

RNA interference-triggered reversal of ABCC2-dependent cisplatin resistance in human cancer cells. Materna V, Stege A, Surowiak P, Priebsch A, Lage H. Biochem Biophys Res Commun. 2006 Sep 15;348(1):153-7. Epub 2006 Jul 14. PMID: 16876126 

Expression of aminopeptidase N/CD13 in human ovarian cancers. Surowiak P, Drag M, Materna V, Suchocki S, Grzywa R, Spaczyński M, Dietel M, Oleksyszyn J, Zabel M, Lage H. Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1783-8. PMID: 17009972

Multivariate analysis of oestrogen receptor alpha, pS2, metallothionein and CD24 expression in invasive breast cancers. Surowiak P, Materna V, Györffy B, Matkowski R, Wojnar A, Maciejczyk A, Paluchowski P, Dziegiel P, Pudełko M, Kornafel J, Dietel M, Kristiansen G, Zabel M, Lage H. Br J Cancer. 2006 Aug 7;95(3):339-46. PMID: 16892043

Inhibition of the multidrug-resistant phenotype by targeting YB-1 with a conditionally oncolytic adenovirus: implications for combinatorial treatment regimen with chemotherapeutic agents. Mantwill K, Köhler-Vargas N, Bernshausen A, Bieler A, Lage H, Kaszubiak A, Surowiak P, Dravits T, Treiber U, Hartung R, Gansbacher B, Holm PS. Cancer Res. 2006 Jul 15;66(14):7195-202. PMID: 16849566

MDR1/P-glycoprotein (ABCB1) as target for RNA interference-mediated reversal of multidrug resistance. Lage H. Curr Drug Targets. 2006 Jul;7(7):813-21. Review. PMID: 16842213

Topoisomerase 1A, HER/2neu and Ki67 expression in paired primary and relapse ovarian cancer tissue samples. Surowiak P, Materna V, Kaplenko I, Spaczynski M, Dietel M, Lage H, Zabel M. Histol Histopathol. 2006 Jul;21(7):713-20. PMID: 16598670

High antineoplastic activity of new heterocyclic compounds in cancer cells with resistance against classical DNA topoisomerase II-targeting drugs. Lage H, Aki-Sener E, Yalcin I. Int J Cancer. 2006 Jul 1;119(1):213-20. PMID: 16450374

Significance of cyclooxygenase 2 and MDR1/P-glycoprotein coexpression in ovarian cancers. Surowiak P, Materna V, Denkert C, Kaplenko I, Spaczyński M, Dietel M, Zabel M, Lage H. Cancer Lett. 2006 Apr 28;235(2):272-80. Epub 2005 Jun 20. PMID: 15970376

Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Györffy B, Surowiak P, Kiesslich O, Denkert C, Schäfer R, Dietel M, Lage H. Int J Cancer. 2006 Apr 1;118(7):1699-712. PMID: 16217747

Maspin expression is characteristic for cisplatin-sensitive ovarian cancer cells and for ovarian cancer cases of longer survival rates. Surowiak P, Materna V, Drag-Zalesinska M, Wojnar A, Kaplenko I, Spaczyński M, Dietel M, Zabel M, Lage H. Int J Gynecol Pathol. 2006 Apr;25(2):131-9. PMID: 16633061

Analysis of gene expression profiles in melanoma cells with acquired resistance against antineoplastic drugs. Györffy B, Serra V, Materna V, Schäfer R, Dietel M, Schadendorf D, Lage H. Melanoma Res. 2006 Apr;16(2):147-55. PMID: 16567970 

Unfavorable prognostic value of CD24 expression in sections from primary and relapsed ovarian cancer tissue. Surowiak P, Materna V, Kaplenko I, Spaczyński M, Dietel M, Kristiansen G, Lage H, Zabel M. Int J Gynecol Cancer. 2006 Mar-Apr;16(2):515-21. PMID: 16681720

CD24 expression is specific for tamoxifen-resistant ductal breast cancer cases. Surowiak P, Materna V, Paluchowski P, Matkowski R, Wojnar A, Maciejczyk A, Pudelko M, Kornafel J, Dietel M, Kristiansen G, Lage H, Zabel M. Anticancer Res. 2006 Jan-Feb;26(1B):629-34. PMID: 16739331 

Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by the c-Jun NH2-terminal kinase. Zhou J, Liu M, Aneja R, Chandra R, Lage H, Joshi HC. Cancer Res. 2006 Jan 1;66(1):445-52. PMID: 16397260

Novel three-pronged strategy to enhance cancer cell killing in glioblastoma cell lines: histone deacetylase inhibitor, chemotherapy, and oncolytic adenovirus dl520. Bieler A, Mantwill K, Dravits T, Bernshausen A, Glockzin G, Köhler-Vargas N, Lage H, Gansbacher B, Holm PS. Hum Gene Ther. 2006 Jan;17(1):55-70. PMID: 16409125


2005

Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival. Györffy B, Serra V, Jürchott K, Abdul-Ghani R, Garber M, Stein U, Petersen I, Lage H, Dietel M, Schäfer R. Oncogene. 2005 Nov 17;24(51):7542-51. PMID: 16044152 

Augmented expression of metallothionein and glutathione S-transferase pi as unfavourable prognostic factors in cisplatin-treated ovarian cancer patients. Surowiak P, Materna V, Kaplenko I, Spaczyński M, Dietel M, Lage H, Zabel M. Virchows Arch. 2005 Sep;447(3):626-33. Epub 2005 Jun 21. PMID: 15968547

Protection of platinum-DNA adduct formation and reversal of cisplatin resistance by anti-MRP2 hammerhead ribozymes in human cancer cells. Materna V, Liedert B, Thomale J, Lage H. Int J Cancer. 2005 Jun 20;115(3):393-402. PMID: 15688364

Transcriptome analysis of different multidrug-resistant gastric carcinoma cells. Heim S, Lage H. In Vivo. 2005 May-Jun;19(3):583-90. PMID: 15875780

Induction of the ABC-transporters Mdr1/P-gp (Abcb1), mrpl (Abcc1), and bcrp (Abcg2) during establishment of multidrug resistance following exposure to mitoxantrone. Nieth C, Lage H. J Chemother. 2005 Apr;17(2):215-23. PMID: 15920909

 Reversal of different drug-resistant phenotypes by an autocatalytic multitarget multiribozyme directed against the transcripts of the ABC transporters MDR1/P-gp, MRP2, and BCRP. Kowalski P, Surowiak P, Lage H. Mol Ther. 2005 Apr;11(4):508-22. PMID: 15771954

Overexpression of cathepsin B in gastric cancer identified by proteome analysis. Ebert MP, Krüger S, Fogeron ML, Lamer S, Chen J, Pross M, Schulz HU, Lage H, Heim S, Roessner A, Malfertheiner P, Röcken C. Proteomics. 2005 Apr;5(6):1693-704. PMID: 15789341

Potential applications of RNA interference technology in the treatment of cancer. Lage H. Future Oncol. 2005 Feb;1(1):103-13. Review. PMID: 16555980

Relationship between the expression of cyclooxygenase 2 and MDR1/P-glycoprotein in invasive breast cancers and their prognostic significance. Surowiak P, Materna V, Matkowski R, Szczuraszek K, Kornafel J, Wojnar A, Pudelko M, Dietel M, Denkert C, Zabel M, Lage H. Breast Cancer Res. 2005;7(5):R862-70. Epub 2005 Aug 25. PMID: 16168133

Prognostic value of immunohistochemical estimation of CD24 and Ki67 expression in cisplatin and paclitaxel treated ovarian carcinoma patients. Surowiak P, Materna V, Kłak K, Spaczyński M, Dietel M, Kristiansen G, Lage H, Zabel M. Pol J Pathol. 2005;56(2):69-74. PMID: 16092668


2004

Stable and complete overcoming of MDR1/P-glycoprotein-mediated multidrug resistance in human gastric carcinoma cells by RNA interference. Stege A, Priebsch A, Nieth C, Lage H. Cancer Gene Ther. 2004 Nov;11(11):699-706. PMID: 15375376

Chromosomal imbalances associated with drug resistance and thermoresistance in human pancreatic carcinoma cells. Tönnies H, Lage H. Eur J Cell Biol. 2004 Oct;83(10):591-601. PMID: 15679104

Effective knock down of very high ABCG2 expression by a hammerhead ribozyme. Kowalski P, Farley KM, Lage H, Schneider E. Anticancer Res. 2004 Jul-Aug;24(4):2231-5. PMID: 15330166

RNA expression of MDR1/P-glycoprotein, DNA-topoisomerase I, and MRP2 in ovarian carcinoma patients: correlation with chemotherapeutic response. Materna V, Pleger J, Hoffmann U, Lage H. Gynecol Oncol. 2004 Jul;94(1):152-60. PMID: 15262134 

New silicon compounds as resistance modifiers against multidrug-resistant cancer cells. Molnar J, Mucsi I, Nacsa J, Hevér A, Gyémánt N, Ugocsai K, Hegyes P, Kiessig S, Gaal D, Lage H, Varga A. Anticancer Res. 2004 Mar-Apr;24(2B):865-71. PMID: 15161039

Glypican-3 is involved in cellular protection against mitoxantrone in gastric carcinoma cells. Wichert A, Stege A, Midorikawa Y, Holm PS, Lage H. Oncogene. 2004 Jan 29;23(4):945-55. PMID: 14661052

Multidrug-resistant cancer cells facilitate E1-independent adenoviral replication: impact for cancer gene therapy. Holm PS, Lage H, Bergmann S, Jürchott K, Glockzin G, Bernshausen A, Mantwill K, Ladhoff A, Wichert A, Mymryk JS, Ritter T, Dietel M, Gänsbacher B, Royer HD. Cancer Res. 2004 Jan 1;64(1):322-8. PMID: 14729641

Study of the development of thermoresistance in human pancreatic carcinoma cell lines using proteome analysis. Poland J, Urbani A, Lage H, Schnölzer M, Sinha P. Electrophoresis. 2004 Jan;25(1):173-83. PMID: 14730581

Proteomics in cancer cell research: an analysis of therapy resistance. Lage H. Pathol Res Pract. 2004;200(2):105-17. Review. PMID: 15237919 


2003

Reversal of breast cancer resistance protein-mediated drug resistance by tryprostatin A. Woehlecke H, Osada H, Herrmann A, Lage H. Int J Cancer. 2003 Dec 10;107(5):721-8. PMID: 14566821

Enhanced exposure of phosphatidylserine in human gastric carcinoma cells overexpressing the half-size ABC transporter BCRP (ABCG2). Woehlecke H, Pohl A, Alder-Baerens N, Lage H, Herrmann A. Biochem J. 2003 Dec 1;376(Pt 2):489-95. PMID: 12946267

Dynamic expression profile of p21WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy. Rau B, Sturm I, Lage H, Berger S, Schneider U, Hauptmann S, Wust P, Riess H, Schlag PM, Dörken B, Daniel PT. J Clin Oncol. 2003 Sep 15;21(18):3391-401. Epub 2003 Jul 28. Erratum in: J Clin Oncol. 2004 Feb 1;22(3):576. PMID: 12885834

ABC-transporters: implications on drug resistance from microorganisms to human cancers. Lage H. Int J Antimicrob Agents. 2003 Sep;22(3):188-99. Review. PMID: 13678820

Study of the development of chemoresistance in melanoma cell lines using proteome analysis. Sinha P, Poland J, Kohl S, Schnölzer M, Helmbach H, Hütter G, Lage H, Schadendorf D. Electrophoresis. 2003 Jul;24(14):2386-404. PMID: 12874874

Overexpression of cMOAT (MRP2/ABCC2) is associated with decreased formation of platinum-DNA adducts and decreased G2-arrest in melanoma cells resistant to cisplatin. Liedert B, Materna V, Schadendorf D, Thomale J, Lage H. J Invest Dermatol. 2003 Jul;121(1):172-6. PMID: 12839578

Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi). Nieth C, Priebsch A, Stege A, Lage H. FEBS Lett. 2003 Jun 19;545(2-3):144-50. PMID: 12804765

Association of genomic imbalances with drug resistance and thermoresistance in human gastric carcinoma cells. Tönnies H, Poland J, Sinha P, Lage H. Int J Cancer. 2003 Mar 1;103(6):752-8. PMID: 12516094

Molecular analysis of therapy resistance in gastric cancer. Lage H. Dig Dis. 2003;21(4):326-38. Review. PMID: 14752223

Homozygous mutation Arg768Trp in the ABC-transporter encoding gene MRP2/cMOAT/ABCC2 causes Dubin-Johnson syndrome in a Caucasian patient. Materna V, Lage H. J Hum Genet. 2003;48(9):484-6. Epub 2003 Aug 27. PMID: 12942343


2002

Identification of differentially expressed genes in classical and atypical multidrug-resistant gastric carcinoma cells. Ludwig A, Dietel M, Lage H. Anticancer Res. 2002 Nov-Dec;22(6A):3213-21. PMID: 12530067

Transport of phosphatidylserine via MDR1 (multidrug resistance 1)P-glycoprotein in a human gastric carcinoma cell line. Pohl A, Lage H, Müller P, Pomorski T, Herrmann A. Biochem J. 2002 Jul 1;365(Pt 1):259-68. PMID: 12071854

Modulation of the atypical multidrug-resistant phenotype by a hammerhead ribozyme directed against the ABC transporter BCRP/MXR/ABCG2. Kowalski P, Stein U, Scheffer GL, Lage H. Cancer Gene Ther. 2002 Jul;9(7):579-86. PMID: 12082458

Multiple mechanisms confer different drug-resistant phenotypes in pancreatic carcinoma cells. Lage H, Dietel M. J Cancer Res Clin Oncol. 2002 Jul;128(7):349-57. Epub 2002 Jun 26. PMID: 12136248

YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter. Holm PS, Bergmann S, Jurchott K, Lage H, Brand K, Ladhoff A, Mantwill K, Curiel DT, Dobbelstein M, Dietel M, Gansbacher B, Royer HD. J Biol Chem. 2002 Mar 22;277(12):10427-34. Epub 2002 Jan 11. PMID: 11788582

Study of therapy resistance in cancer cells with functional proteome analysis. Poland J, Schadendorf D, Lage H, Schnölzer M, Celis JE, Sinha P. Clin Chem Lab Med. 2002 Mar;40(3):221-34. Review. PMID: 12005211

Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells. Stein U, Lage H, Jordan A, Walther W, Bates SE, Litman T, Hohenberger P, Dietel M. Int J Cancer. 2002 Feb 20;97(6):751-60. PMID: 11857350


2001

Enhanced expression of human ABC-transporter tap is associated with cellular resistance to mitoxantrone. Lage H, Perlitz C, Abele R, Tampé R, Dietel M, Schadendorf D, Sinha P. FEBS Lett. 2001 Aug 17;503(2-3):179-84. PMID: 11513878

Characterization of the differential protein expression associated with thermoresistance in human gastric carcinoma cell lines. Sinha P, Poland J, Schnölzer M, Celis JE, Lage H. Electrophoresis. 2001 Aug;22(14):2990-3000. PMID: 11565793

Expression of a glypican-related 62-kDa antigen is decreased in hepatocellular carcinoma in correspondence to the grade of tumor differentiation. Lage H, Kellner U, Tannapfel A, Dietel M. Virchows Arch. 2001 Jun;438(6):567-73. PMID: 11469688

DFNA5 (ICERE-1) contributes to acquired etoposide resistance in melanoma cells. Lage H, Helmbach H, Grottke C, Dietel M, Schadendorf D. FEBS Lett. 2001 Apr 6;494(1-2):54-9. PMID: 11297734

Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT. Christmann M, Pick M, Lage H, Schadendorf D, Kaina B. Int J Cancer. 2001 Apr 1;92(1):123-9. PMID: 11279615

Selection and characterization of a high-activity ribozyme directed against the antineoplastic drug resistance-associated ABC transporter BCRP/MXR/ABCG2. Kowalski P, Wichert A, Holm PS, Dietel M, Lage H. Cancer Gene Ther. 2001 Mar;8(3):185-92. PMID: 11332989

Kinetic characterization of ribozymes directed against the cisplatin resistance-associated ABC transporter cMOAT/MRP2/ABCC2. Materna V, Holm PS, Dietel M, Lage H. Cancer Gene Ther. 2001 Mar;8(3):176-84. PMID: 11332988 


2000

Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs. Grottke C, Mantwill K, Dietel M, Schadendorf D, Lage H. Int J Cancer. 2000 Nov 15;88(4):535-46. PMID: 11058868 

Effect of the breast-cancer resistance protein on atypical multidrug resistance. Lage H, Dietel M. Lancet Oncol. 2000 Nov;1:169-75. Review. PMID: 11905655

Identification of novel proteins associated with the development of chemoresistance in malignant melanoma using two-dimensional electrophoresis. Sinha P, Kohl S, Fischer J, Hütter G, Kern M, Köttgen E, Dietel M, Lage H, Schnölzer M, Schadendorf D. Electrophoresis. 2000 Aug;21(14):3048-57. PMID: 11001322

Thermosensitivity of multidrug-resistant human gastric and pancreatic carcinoma cells. Lage H, Jordan A, Scholz R, Dietel M. Int J Hyperthermia. 2000 Jul-Aug;16(4):291-303. PMID: 10949126

Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance. Lage H, Helmbach H, Dietel M, Schadendorf D. Br J Cancer. 2000 Jan;82(2):488-91. PMID: 10646909