Sie befinden sich hier:


Ausgewählte Publikationen

Merkelbach-Bruse S, Rehker J, Siemanowski J, Klauschen F. Detection and interpretation of somatic variants in molecular pathology. Pathologe. 2019 Apr 29.

Cabeza-Cabrerizo M, van Blijswijk J, Wienert S, Heim D, Jenkins RP, Chakravarty P, Rogers N, Frederico B, Acton S, Beerling E, van Rheenen J, Clevers H, Schraml BU, Bajénoff M, Gerner M, Germain RN, Sahai E, Klauschen F*, Reis E Sousa C*. Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors. Science Immunology 2019 Mar 1;4(33).*Co-corresponding author.

Klauschen F. Systems proteogenomics for precision oncology. Oncotarget. 2019 Jan 22;10(7):692-693.

Treue D, Bockmayr M, Stenzinger A, Heim D, Hester S, Klauschen F. Proteogenomic systems analysis identifies targeted therapy resistance mechanisms in EGFR-mutated lung cancer. Int J Cancer. 2019 Feb 1;144(3):545-557.

Heim D, Montavon G, Hufnagl P, Müller KR, Klauschen FComputational analysis reveals histotype-dependent molecular profile and actionable mutation effects across cancers. Genome Med. 2018 Nov 15;10(1):83.

Klauschen F, Müller KR, Binder A, Bockmayr M, Hägele M, Seegerer P, Wienert S, Pruneri G, de Maria S, Badve S, Michiels S, Nielsen TO, Adams S, Savas P, Symmans F, Willis S, Gruosso T, Park M, Haibe-Kains B, Gallas B, Thompson AM, Cree I, Sotiriou C, Solinas C, Preusser M, Hewitt SM, Rimm D, Viale G, Loi S, Loibl S, Salgado R, Denkert C; International Immuno-Oncology Biomarker Working Group. Scoring of tumor-infiltrating lymphocytes: From visual estimation to machine learning. Semin Cancer Biol. 2018 Oct;52(Pt 2):151-157.

Baratin M, Simon L, Jorquera A, Ghigo C, Dembele D, Nowak J, Gentek R, Wienert S, Klauschen F, Malissen B, Dalod M, Bajénoff M. T Cell Zone Resident Macrophages Silently Dispose of Apoptotic Cells in the Lymph Node. Immunity. 2017 Aug 15;47(2):349-362

Mamlouk S, Childs LH, Aust D, Heim D, Melching F, Oliveira C, Wolf T, Durek P, Schumacher D, Bläker H, von Winterfeld M, Gastl B, Möhr K, Menne A, Zeugner S, Redmer T, Lenze D, Tierling S, Möbs M, Weichert W, Folprecht G, Blanc E, Beule D, Schäfer R, Morkel M, Klauschen F, Leser U, Sers C. DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer. Nature Commun. 2017 Jan 25;8:14093. link to 3D tumor model

Mondor I, Jorquera A, Sene C, Adriouch S, Adams R, Zhou B, Wienert S, Klauschen F and Bajenoff M. Clonal proliferation and stochastic pruning orchestrate lymph node vasculature remodeling, Immunity, 2016. 

Klauschen F, Bläker H, Stenzinger A, Chapman JS, Collisson EA, Taylor BS. "Clinical Sequencing Contributes to a BRCA-Associated Cancer Rediagnosis That Guides an Effective Therapeutic Course". J Natl Compr Canc Netw. 2016 Mar;14(3):lxvi-lxviii. 

von Laffert M, Stenzinger A, Hummel M, Weichert W, Lenze D, Warth A, Penzel R, Herbst H, Kellner U, Jurmeister P, Schirmacher P, Dietel M, Klauschen F. ALK-FISH borderline cases in non-small cell lung cancer: Implications for diagnostics and clinical decision making. Lung Cancer. 2015 Dec;90(3):465-71.

Eickhoff S, Brewitz A, Gerner MY,  Klauschen F, Komander K, Hemmi H, Garbi N, Kaisho T, Germain RN, Kastenmüller W. Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions. Cell. 2015 Sep 10;162(6):1322-37. 

Stenzinger A, Weichert W, Lennerz JK, Klauschen F. Basket Trials: Just the End of the First Quarter. J Clin Oncol. 2015 Sep 1;33(25):2823-4. 

Denkert C, Budczies J, von Minckwitz G, Wienert S, Loibl S, Klauschen F. Strategies for developing Ki67 as a useful biomarker in breast cancer. Breast. 2015 Nov;24    

Klauschen F, Wienert S, Schmitt W, Loibl S, Gerber B, Blohmer JU, Huober J, Ruediger T, Erbstoesser E, Mehta K, Lederer B, Dietel M, Denkert C, von Minckwitz G. Standardized Ki67 diagnostics using automated scoring - clinical validation in the GeparTrio breast cancer study. Clin Cancer Res. 2014 Dec 11.

Klauschen F. Mutational tumor profiles beyond organ and tissue specificity: implications for diagnostics and clinical study design. Pathologe. 2014 Nov;35 Suppl 2:277-80. 

Klauschen F, Andreeff M, Keilholz U, Dietel M, Stenzinger A. The combinatorial complexity of cancer precision medicine. Oncoscience. 2014 Jul 23;1(7):504-9.

van Panhuys N, Klauschen F, Germain RN. T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization In Vivo. Immunity. 2014 Jul 17;41(1):63-74. 

Jarjour M, Jorquera A, Mondor I, Wienert S, Narang P, Coles M, Klauschen F, Bajenoff M. Fate mapping reveals Origin and Dynamics of lymph node Follicular Dendritic Cells. Exp Med. 2014 Jun 2;211(6):1109-22. 

Heim D, Budczies J, Stenzinger A, Treue D, Hufnagl P, Denkert C, Dietel M, Klauschen F. Cancer beyond organ and tissue specificity: Next-generation-sequencing gene mutation data reveal complex genetic similarities across major cancers. Int J Cancer. 2014 Apr 7.      

Ghigo C, Mondor I, Jorquera A, Nowak J, Wienert S, Zahner SP, Clausen BE, Luche H, Malissen B, Klauschen F*, Bajénoff M. Multicolor fate mapping of Langerhans cell homeostasis. J Exp Med. 2013 Aug 26;210(9):1657-64. *Co-senior author.

Brandes M, Klauschen F, Kuchen S, Germain RN. A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection. Cell. 2013 Jul 3;154(1):197-212.    

Stenzinger A, von Winterfeld M, Aulmann S, Warth A, Weichert W, Denkert C, Ruschoff J, Dietel M, Klauschen F. Quantitative analysis of diagnostic guidelines for HER2-status assessment. The Journal of molecular diagnostics : JMD 2012;14:199-205.

Mandl JN, Liou R, Klauschen F, Vrisekoop N, Monteiro JP, Yates AJ, Huang AY, Germain RN. Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naive CD4+ and CD8+ T cells. PNAS. 2012 Oct 30;109(44):18036-41. 

Angermann BR, Klauschen F*, Garcia AD, Prustel T, Zhang F, Germain RN, Meier-Schellersheim M. Computational modeling of cellular signaling processes embedded into dynamic spatial contexts. Nature Methods 2012;9:283-9. *Co-First Author.

Klauschen F, Qi H, Egen JG, Germain RN, Meier-Schellersheim M. Computational reconstruction of cell and tissue surfaces for modeling and data analysis. Nature protocols 2009;4:1006-12.    

Ishii M, Egen JG, Klauschen F, Meier-Schellersheim M, Saeki Y, Vacher J, Proia RL, Germain RN. Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. Nature. 2009 Mar 26;458(7237):524-8. 

Klauschen F, Ishii M, Qi H, Bajenoff M, Egen JG, Germain RN, Meier-Schellersheim M. Quantifying cellular interaction dynamics in 3D fluorescence microscopy data. Nature protocols 2009;4:1305-11. 

Qi H, Cannons JL, Klauschen F, Schwartzberg PL, Germain RN. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature. 2008 Oct 9;455(7214):764-9.